Tenofovir disoproxil fumarate (TDF) is listed by the World Health Organization (WHO) as an essential medicine in the healthcare system. Its effectiveness is impressive. It’s one of the medicines used to treat hepatitis B virus and HIV infection.
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Showing 1–16 of 24 results
Viread, designed and patented by Gilead Sciences, contains the active ingredients of tenofovir disoproxil fumarate. It has been approved (and its generics are tentatively approved) by the U.S. Food and Drug Administration (FDA) for HIV treatment.
Emcure markets the generic version of TDF under the name Tavin. There are other generics and brand-name versions of TDF, which we’ll cover in this article. Since its approval, tenofovir has become the world’s top safest, efficacious, and tolerable drug of antiretroviral regimens.
TDF (a prodrug of tenofovir) designed, manufactured, and marketed by Gilead Sciences under the brand name Vireal is a NRTIs drug used together with other antiretroviral therapies in treatment of HIV-1 infection. It’s prescribed to be used in HIV-1 and chronic HBV patients.
Tenofovir DF is also indicated for use in amalgamation with other meds (like emtricitabine) for HIV-1 pre-exposure prophylaxis (PrEP) prevention to help decrease the danger of sexually acquired HIV-1 infection.
Tenofovir DF is a medication from a group of HIV drugs known as nucleoside reverse transcriptase inhibitors (common abbreviation - NRTIs) – a group of inhibitors that block HIV enzymes (necessary for viral production) in HIV-infected individuals, thus preventing the virus from multiplying.
After an oral dosage of tenofovir to patients with HIV infection, TDF is swiftly soaked up and metabolized to tenofovir, an inhibitor required for blocking the HIV virus from increasing.
TDF can’t cure HIV. Its purpose is to reduce the virus and make it weaker. In this case, tenofovir DF is used in addition with other meds (HIV regimen) for treatment of patients living with HIV to make them stay healthier and live longer.
Tenofovir DF is prescribed to be used in addition with other antiretroviral agents to heal:
Allergy to TDF (adenosine analogs), decreased levels of phosphate in the blood, raised levels of blood acidity, and kidney problems are some of the contraindications.
Warnings and precautions:
There are other precautions that your doctor should inform you of based on your health condition before initiating TDF medication.
It’s very important for your doctor or healthcare provider to assess if you’re diagnosed with kidney problems, liver problems including hep B infection, or certain bone problems. It’s also important for your doctor to know if you’re pregnant or have the forethought to be pregnant. There is no prescribing information if TDF will harm the fetus.
TDF contains both tablet and oral border. The table consists of 150 mg, 200 mg, 250 mg, and 300 mg of active ingredient. Only oral powder is packaged in 40 mg.
Adults and patients weighing more than 35 kg should take one tablet (300 mg) per day, regardless of meals.
Here is a breakdown of dosage recommendations for patients older than 2 years:
Only measure oral powder with the given dosing scoop. Keep in mind that:
TDF drug powder is only mixed with soft foods, because it should be swallowed without chewing. It's best not to mix TDF powder with liquid as the drug powder may not mix well.
The following are the side effects that patients might experience during their treatment with TDF drug.
Major side effects may manifest as:
Mild to moderate side effects:
The drug may cause liver problems. If you see any of the below symptoms of liver problems, visit your doctor or healthcare provider immediately:
There are other symptoms that show the signs of kidney problems when using tenofovir. Inform your doctor if you are experiencing little or no urination, feeling tired, painful or difficult urination, shortness of breath, or swelling in your feet or ankles.
Follow the prescription diligently as advised by your doctor. If it happens that you take too much tenofovir (overdose), immediately call your healthcare provider or seek medical aid.
As with all other medications, some medicines can interact with certain foods, which may cause some harmful effect on your health. Tenofovir has no specific foods that you must avoid when using tenofovir pills.
There are various drugs that can cause harmful effect if co-administered with TDF. Some of these meds include the tablets affecting renal function, which may potentially increase concentrations of tenofovir.
Examples include drugs used in treating chronic hepatitis B. In this case, TDF should not be taken in combination with Hepsera or Adesera (adefovir dipivoxil).
Other drugs include:
Do not use TDF with any other medicines with the same active ingredient such as Atripla, Telura, Complera, and Truvada – these drugs increase the quantity of TDF in your body, leading to overdose.
This list is not complete. It’s best to inform your doctor of all the medication you’re using, either prescription drugs, over-the-counter, vitamins and herbals supplements, or any other type of drug you’re using, in order to assess if it’s causing harmful effects if taken with tenofovir.
It’s always recommended to avoid an excessive amounts of alcohol and street drugs while you are taking TDF. Alcohol may interact with some of the medications and may increase your chance of liver damage.
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TDF is available in our pharmacy in products such as Tavin (from Emcure), Teravir (from Natco), Tenof (from Hetero) or in combination with other substances, such as Tenvir-EM (from Cipla) and Teevir (from Mylan).
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