Emtricitabine and tenofovir disoproxil fumarate (DF) is an effective medication approved by the US Food and Drug Administration (FDA) for the prevention (when used for PrEP, which stands for pre-exposure prophylaxis) and control of HIV/AIDS.
Showing 1–16 of 24 results
Showing 1–16 of 24 results
Emtricitabine and tenofovir is an effective combination drug for PrEP, and if taken as prescribed, can lower the risk of getting infected with HIV during sex by 90%, and through blood transfusion by 70%. The procedure only requires that a single pill be taken every day. It is advised that the pill is taken at the same time every day to help users avoid missing a dose. The pills can be taken with or without food. Strict adherence to the medication can help to both prevent non-infected people from contracting the virus and enable already infected people to live very healthy and normal lives.
People infected with HIV need a regimen with lower toxicity, fewer side effects, simple dosing, and that is safe and tolerable. Together, tenofovir and emtricitabine disoproxil fumarate (DF) make a great combination that offers the aforementioned qualities users of the drug need. This med is a very recent fixed-dose combination and as such, it far exceeds traditional antiretrovirals in terms of safety (fewer possible side effects), ease of use, and efficiency.
This combination serves also as an effective treatment for hepatitis B and can be used by individuals co-infected with both hepatitis B and HIV. However, patients with renal insufficiency must exercise caution when using it, especially when it is to be taken with other drugs.
Tenofovir and emtricitabine combination as a regimen is well tolerated and safe even when used for extended periods. It has helped improve adherence, reduce morbidity and mortality rate, as its dosing is convenient - needed to be taken only once a day.
Generally, for HIV to reproduce and spread throughout the body, it requires a certain enzyme known as reverse transcriptase. Cells infected with HIV use this enzyme to kickstart replication, i.e. making more HIV copies.
Together, Tenofovir and emtricitabine interfere with the enzyme (reverse transcriptase), causing the HIV-infected cells to slow down or stop producing new copies of themselves.
Also, being able to inhibit the replication of the virus upon entry into the body (by oral administration), the drug prevents the virus from permanently infecting the cells, thereby reducing the possibility of an HIV non-infected individual contracting the virus.
However, it is worthy of note that this drug does not replace all other HIV prevention options such as the use of condoms, which also protect against STIs (sexually transmitted infections) like chlamydia, etc.
Certain side effects may arise if Emtricitabine and Tenofovir DF are not used correctly. In this light, care must be taken while using the drug to prevent these harmful effects from surfacing. Here are warnings about emtricitabine and tenofovir intake and precautions to take:
Having listed warnings associated with emtricitabine and tenofovir intake, here are some precautionary measures that should be taken to avoid complications with intake of the drug:
People infected with HIV have to use more medicines alongside emtricitabine and tenofovir DF during the process of treatment. These components alone cannot effectively treat HIV-1. If you have HIV-1 and you depend on this regimen only, it may be difficult to treat your HIV now, as well as in the future.
Though this regimen is highly effective for PrEP, and for HIV treatment when used alongside other antiretroviral drugs, it may not work or could even lead to serious complications if it is not taken correctly.
For emtricitabine and tenofovir DF to work as it is designed to, the correct dosage must be taken, and at the right time as well:
Please discuss with your health care provider in order to determine the correct amount of dosage for all patients (adults and children). Any discomfort experienced with the usage of the tablets should be reported as well.
Alongside the good benefits of this drug, it may also lead to some adverse reactions. The possible side effects may range from manageable ones such as headaches, fatigue, and stomach upset, to more severe ones such as body aches, difficulty in breathing, and blisters under the skin. Regardless, because the benefit of this drug far outweighs its downside, it remains a trusted drug for the treatment of HIV and continues to be used.
Fortunately, new regimens for HIV treatment are developed every day, and they pose way fewer side effects than the older ones. With the use of newer regimens, infected individuals are less likely to suffer side effects.
Common side effects of this medication usually include:
These effects may not be experienced by every user of this drug. For those who experience it, they may vanish within weeks of strict adherence to the medication, as the body makes an adjustment. Any form of discomfort (side effect) should be reported to a doctor or healthcare provider who may provide tips to help manage or prevent them.
Up till now, direct trials have not been carried on Truvada to determine how it interacts with other drugs, foods, and supplements. However, trials have been carried out on the individual active components of the drug (i.e. emtricitabine and tenofovir DF).
The clinically relevant drugs interactions with the two components include:
For complete information, contact your pharmacist.
A majority of active users of Truvada for PrEP have attested to its effectiveness in preventing HIV infections. A greater part of them have reported little or no side effects. Same goes to the HIV positive patients taking Truvada as part of their regimen.
However, a few people complained about experiencing dizziness, headaches, stomach upset, vomiting, or fatigue at the early stage of commencing the medication. While some of these users who made these complaints reported the disappearance of the side effects within a little over a week, others said the side effects took about two weeks to subside.
Overall, going by the reviews of very many emtricitabine and tenofovir DF users, the drug is considered to be very good in terms of both ease of use and its effectiveness in reducing the possibility of getting infected with HIV.
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