Generic Sovaldi (trade name for sofosbuvir) is a highly effective OTC medication used to treat hepatitis C (HCV) virus. It’s the breakthrough antiviral medicine that treats adults with HCV with or without cirrhosis (compensated) by directly targeting the hep C virus in the body.
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Generic versions of Sovaldi are available at a very cheap price. But don’t equate cheaper prices with low quality and ineffectiveness. This drug does the perfect job of treating and curing HCV infections.
Sovaldi generic (marketed under the brand name Sovaldi by Gilead Sciences) 400 mg tablet is an effective, high-quality medication that functions equivalently to the brand-name version but is available at the lowest cost to address the expensive prices of Sovaldi brand medications.
Sovaldi is among the WHO’s list of the most essential medicines needed in a basic health care system. It is only recommended being used with some combination of other drugs such as simeprevir, peginterferon-alfa, ribavirin, and more.
It is a more effective and better-tolerated treatment of hepatitis C (also known as hep C) than its alternative treatments (its cure rate goes up to 97% depending on the type of HCV involved in a patient).
Sovaldi is a direct-acting antiviral medicine that targets different steps of the HCV lifecycle. It works by blocking the polymerase enzyme, which the hep C virus must use to reproduce.
The use of Sovaldi is recommended with some combinations of other medications including daclatasvir, ribavirin, ledipasvir, peginterferon-alfa, velpatasvir, simeprevir or other direct-acting antivirals medicines. Never use Sovaldi alone as a treatment for hep C.
As a combination drug, Generic Sovaldi sofosbuvir works with hepatitis C genotype 1, 2, 3 and 4. The medication lasts from 12 to 24 weeks, depending on the patient genotype.
Patients with hep C genotype (GT) 1 and 4 infections are treated with a drug combination of sofosbuvir, peginterferon and ribavirin. Generic Sovaldi sofosbuvir is prescribed in combination with ribavirin in patients with GT 2 & 3 infections.
Generic Sovaldi sofosbuvir is available in a 400 mg dosage. It’s taken orally – one tablet daily with or without food.
Other than being used to treat adult patients diagnosed with chronic HCV infection in combinations with other antiviral treatment regimens as stated above, Sovaldi can be used together with ribavirin as a remedy for chronic HCV GT 1 or 2 infections in pediatric patients without cirrhosis or compensated cirrhosis (see table below).
Here is a comprehensive table detailing all of the advisable treatment regimens and the time it takes in patients with GT 1, 2, 3, or 4 hep C.
|Genotype (GT)||Patient treatment regimen||Period (in weeks)|
|1 or 4||sofosbuvir + ribavirin + peginterferon alfa-2a||12|
|2||sofosbuvir + ribavirin||12|
|3||sofosbuvir + ribavirin||24|
The dosage of ribavirin is based on patient's weight. See table.
|Body weight (kg)||Ribavirin daily dosage (mg)|
|< 47||15 mg per kg|
|47 – 49||600|
|50 – 65||800|
|66 – 80||1000|
Generic Sovaldi can be used by patients with all stages of liver disease. If they’re awaiting liver transplant, sofosbuvir can be administered for up to 48 weeks in combination with ribavirin or until liver transplantation to prevent post-transplant HCV.
With sofosbuvir effectiveness in treating hepatitis C virus, it’s reported that patients with HCV who are awaiting or have undergone a liver transplant tolerate Sovaldi better than other medications.
There are some fulminant conditions that may arise in patients living with hep C when they take generic Sovaldi medication. In this case, it is recommended that the doctor test the patients’ health to find out if any of the following conditions are present:
It is not known if Sovaldi is safe to use during pregnancy or while breastfeeding. It’s recommended not to use it unless it’s absolutely necessary.
Generic Sovaldi drugs are highly effective and tolerable for most patients in treating HCV.
But like any other drug, there are some commons side effects of Sovaldi, including diarrhea, nausea, insomnia, fatigue, flu-like illness, fever, rash, decreased appetite, headache, anemia, joint pain, and irritability.
Major side effects can involve thoughts of suicide, pale skin, neutropenia, pancytopenia, dizziness, depression, difficulty sleeping, weakness, itchy/swelling (of the face/throat/tongue), fever, chills, fast heartbeat, and shortness of breath.
This is not a thorough list of possible negative reactions of sofosbuvir. If any of these effects persist or worsen, seek medical help as soon as possible. Inform your doctor or pharmacist promptly.
The effectiveness of generic Sovaldi can be affected by some medications you might be currently using.
It’s very important to inform your doctor or pharmacist to assess any of the drugs you’re currently using. It can be over-the-counter medications, herbal treatments or dietary supplements.
Generic Sovaldi is known to react with the following types of drugs:
Interaction with alcohol is unknown but do consult with your doctor before drinking. It’s very important to know that Sovaldi interactions with rifampicin (rifampin), carbamazepine, and phenytoin medicines are very severe.
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Generic Sovaldi works as effectively as the original brand drug. Since Mylan has received WHO prequalification for generic Sovaldi, its cost has been substantially lower compared to the US hepatitis C treatment with Sovaldi, which cost around $84,000. This price is very high, especially for patients from developing countries like India and across Asia and Africa.
Today, the price of generic Sovaldi 400 mg is more than 95% cheaper, has the same formulation and effectiveness as the original drug and can be used OTC with doctors’ approval.
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