Tenofovir and emtricitabine is a great drug for the prevention of HIV infection through PrEP (that stands for pre-exposure prophylaxis). PrEP is a treatment strategy that can help people at high risk of contracting HIV reduce the risks of getting infected through sex.
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Showing 1–16 of 24 results
Truvada is highly effective but its price is somewhat on the high side, costing over $2,000 for a 30-day supply. Fortunately, just like a good number of other life-saving drugs, generic versions that are way cheaper than the brand drug are available for purchase.
Generic drugs are drugs that are designed with exactly the same active ingredients, have the same mechanism of action and quality as the brand drug, but with a different name and packaging. They always go for a way cheaper price compared to the brand-name drugs as they are an opportunity for pharmaceutical industries to continue selling after the patent for the brand or original drugs expire.
HIV pre-exposure prophylaxis (or shortly PrEP) is a strategy that involves the use of a fixed-dose combination drug containing two antiretroviral medicines - emtricitabine and tenofovir under a brand name called Truvada, to prevent HIV/AIDS infection. It is recommended that individuals who intend to partake in PrEP carry out tests to determine their HIV status before starting, and at least every 3 months during its use. People who are already infected with HIV should not partake in PrEP as complications could arise.
PrEP is so effective that if taken as prescribed, it can reduce the risk of getting infected with HIV through sex by 90%, and through blood transfusion by 70%. The procedure requires the daily consumption of a single pill with or without food at the same time every day.
PrEP alone is effective in HIV prevention, however, when used alongside other preventive methods such as condoms, greater protection can be achieved. It is also used in the control or management of chronic hepatitis B (HBV), as PrEP drugs (Truvada for example) contains tenofovir (one of the most effective treatments for HBV).
The estimated time for PrEP to assume “maximum protection” of the body from HIV is 7-20 days if the pills are taken as prescribed. (It takes 7 days for PrEP to reach full protection in vaginal tissues, and rectal tissues, and 20 days in the blood). From this time, Truvada (the approved drug for PrEP) reduces the risk of contracting the virus by 92-99%.
Though PrEP is a highly effective anti-HIV procedure, unlike condoms, it does not offer protection against STIs like chlamydia, gonorrhea, or syphilis. Neither does it protect against pregnancy. To get better coverage both from HIV and STIs, it is advisable to use condoms alongside PrEP.
There are only a handful of drugs that are appropriate for PrEP, and people need to make sure they are buying the real thing.
Appropriate medications for PrEP that can reduce risks of HIV infection by over 90% are a combination of tenofovir DF and emtricitabine. They must contain 300 mg and 200 mg of the aforementioned active ingredients respectively. Tested generic medications for PrEP include:
In accordance with the US Public Health Service Working Group Recommendations, the dosage for all PrEP drugs (including those listed above) is the same. For any of the listed drugs, 1 tablet should be taken orally, once daily.
Intending users are advised to consult with their healthcare providers to enable them to choose the right medication. Prescriptions must be strictly adhered to if the best results are to be gotten. These drugs should never be taken in more or lesser quantities than recommended, to avoid any complications.
HIV PrEP drugs are safe for consumption as they have not been found to interact with alcohol, foods, and supplements in harmful ways. However, some people experience some side effects such as headaches, dizziness, and nausea, but they disappear over time. While on PrEP, any experience of discomforts of any sort should be reported to a healthcare provider.
Moreover, comprehensive guidelines are always laid down to guide users so as to prevent complications from arising. Attention should be paid to them. Furthermore, prescriptions must be followed; more or less of the recommended dose should not be taken as this could cause unwanted side effects.
Lastly, though alcohol does not interact with the drug, if it is found that the use of alcohol is making it difficult to follow the prescription, its intake should be halted immediately.
To get the best from HIV PrEP drugs, the directives of healthcare providers should be followed to the letter.
Side effects associated with PrEP may be split into two categories, depending on the time they take to surface. They include:
Possible short-term side effects associated with Truvada include vomiting, dizziness, nausea, headache, gastrointestinal symptoms, and fatigue. Most of the time, these side effects surface only during the beginning period of using PrEP and vanish within a few weeks. What’s more, not every PrEP user experiences these symptoms; findings show that only about 1 in 10 people experience these side effects.
On the other hand, long-term side effects that may arise with the use of Truvada include loss of bone mineral density, and reduced kidney function may be experienced by long-time users of Truvada. The side effects which are believed to be caused by one of the active ingredients (tenofovir) of the drug disappear when PrEP is discontinued.
Moreover, facts obtained from an in-depth study of the effects of the drug show that it poses very little to no inconvenience to the young population who use it for only a short period of time.
A drug interaction is a reaction which takes place between two (2) or more drugs, food, or supplement, causing a delay or decrease in the absorption of the drug. If drug interactions are not checked during a treatment, it could cause complications or add to the severity of possible side effects associated with the use of Truvada. There are 3 (three) different kinds of drug interaction, they include:
Up till now, it is not an established fact that Truvada interacts with food, supplements, or alcohol in a way that is unsafe for users. Regardless, people who are on non-steroidal anti-inflammatory drugs (NSAIDS) such as diclofenac, ibuprofen, and naproxen (that have an effect on the kidney) are advised to take precaution if they are to use both drugs simultaneously.
Healthcare providers should be informed of all drugs being used at the time the use of Truvada is to be initiated.
Findings from trials carried out to investigate how Truvada interacts with food show that it actually interacts with certain foods, but in a way that could increase its effectiveness. It was discovered that taking Truvada after a meal can boost its effectiveness by way of increasing the drug level within the user by up to 30%.
However, this extra 30% is considered to be of no clinical importance as the concentration of the constituent ingredients that make up Truvada are sufficient enough to tackle the infection.
Apart from some of the possible side effects that ensue during the early weeks of starting PreP, they are efficient, easy to take, and most users find it satisfactory.
Lots of Truvada users have given positive feedback based on the effectiveness and ease of use of the drug. Though a few reported experiencing side effects such as dizziness, headaches, and vomiting during the initial period of using the drug, they indicated the gradual disappearance of the side effects within weeks from consistent, correct use.
There are also a few users of Truvada who have left negative reviews after using the drug for a short while. A majority of these reports center on side effects experienced. However, there are correct ways to use this drug, and users complaining about severe side effects that would not go away could be using the drug incorrectly.
Overall, positive reviews of Truvada outnumber the negative ones and the drug is considered very satisfactory.
PrEP medications are on sale online and can be bought from online pharmacies.
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The process is really as simple as it reads. A wide range of other medicines for PrEP and HIV treatment are also available on the platform and they can all be bought at a good price. Free samples can also be ordered on the platform.
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