Emtricitabine and Tenofovir Disoproxil Fumarate

Purchase Emtricitabine and Tenofovir DF for PrEP

Emtricitabine and tenofovir is an effective combination drug for PrEP, and if taken as prescribed, can lower the risk of getting infected with HIV during sex by 90%, and through blood transfusion by 70%. The procedure only requires that a single pill be taken every day. It is advised that the pill is taken at the same time every day to help users avoid missing a dose. The pills can be taken with or without food. Strict adherence to the medication can help to both prevent non-infected people from contracting the virus and enable already infected people to live very healthy and normal lives.

Combination of Active Components Tenofovir and Emtricitabine DF

People infected with HIV need a regimen with lower toxicity, fewer side effects, simple dosing, and that is safe and tolerable. Together, tenofovir and emtricitabine disoproxil fumarate (DF) make a great combination that offers the aforementioned qualities users of the drug need. This med is a very recent fixed-dose combination and as such, it far exceeds traditional antiretrovirals in terms of safety (fewer possible side effects), ease of use, and efficiency.

This combination serves also as an effective treatment for hepatitis B and can be used by individuals co-infected with both hepatitis B and HIV. However, patients with renal insufficiency must exercise caution when using it, especially when it is to be taken with other drugs.

Tenofovir and emtricitabine combination as a regimen is well tolerated and safe even when used for extended periods. It has helped improve adherence, reduce morbidity and mortality rate, as its dosing is convenient - needed to be taken only once a day.

How Do They Work Together?

Generally, for HIV to reproduce and spread throughout the body, it requires a certain enzyme known as reverse transcriptase. Cells infected with HIV use this enzyme to kickstart replication, i.e. making more HIV copies.

Together, Tenofovir and emtricitabine interfere with the enzyme (reverse transcriptase), causing the HIV-infected cells to slow down or stop producing new copies of themselves.

Also, being able to inhibit the replication of the virus upon entry into the body (by oral administration), the drug prevents the virus from permanently infecting the cells, thereby reducing the possibility of an HIV non-infected individual contracting the virus.

However, it is worthy of note that this drug does not replace all other HIV prevention options such as the use of condoms, which also protect against STIs (sexually transmitted infections) like chlamydia, etc.

Warnings About Emtricitabine and Tenofovir Intake

Certain side effects may arise if Emtricitabine and Tenofovir DF are not used correctly. In this light, care must be taken while using the drug to prevent these harmful effects from surfacing. Here are warnings about emtricitabine and tenofovir intake and precautions to take:

• possible risk of patients developing resistance to HIV-1 drugs based on incorrect usage: There is a possible risk of developing resistance to HIV drugs if this medicine is not taken exactly as prescribed. This drug only works best when the proper concentration required to halt HIV replication in the body is kept at a constant level. More or less of this medication should not be taken even for a short duration as this may increase the viral load, worsen side effects, and enable the virus to develop resistance. A good way to follow the prescription is to take the drug at the same time each day. This may help you remember to take the drug daily;
• post-treatment aggravation: Tenofovir and emtricitabine should not be started and stopped at any time to prevent aggravation of the disease. Should one need to stop or switch the medication, it is important that the patient is placed under close laboratory and clinical monitoring for months after stopping the therapy. This is to determine the efficiency of the hepatic function;
• this combination is not approved for treatment for HBV infection: Emtricitabine and tenofovir is not an effective medicine for the treatment of HBV. Individuals co-infected with both HBV and HIV should turn to other drugs for effective control of the virus. An antiretroviral (ARV) regiment that includes (TAF or TDF) plus (3TC or FTC) as the nucleoside reverse transcriptase inhibitor (NRTI) backbone will be a better drug.

Having listed warnings associated with emtricitabine and tenofovir intake, here are some precautionary measures that should be taken to avoid complications with intake of the drug:

• emtricitabine and tenofovir are not prescribed for PrEP if a person has unknown HIV status. People who intend to use this drug must first be sure that they are HIV-negative before and during its use. If you think you were exposed to HIV-1, inform your doctor immediately;
• due to the fact that, sometimes, tests might not detect HIV-1 infection in persons at early stages after unprotected sexual intercourse, you should report to your healthcare provider about all symptoms the month before the beginning of your treatment (or even during the treatment) with emtricitabine and tenofovir. That’s because some flu-like symptoms can often be a sign of recent HIV infection;
• though this regimen is highly effective for PrEP and greatly reduces the possibility of getting an HIV infection, the use of other forms of protection (condoms for example) is advised. Users must try not to miss doses as it may significantly increase the chances of getting this infection;
• truvada should not be discontinued by patients and uninfected individuals on the drug without a healthcare provider’s knowledge;
• patients and uninfected individuals should pay regular visits to a physician for a checkup while on Truvada;
• serious efforts must be put in to avoid missing doses.

People infected with HIV have to use more medicines alongside emtricitabine and tenofovir DF during the process of treatment. These components alone cannot effectively treat HIV-1. If you have HIV-1 and you depend on this regimen only, it may be difficult to treat your HIV now, as well as in the future.

Dosage Instructions

Though this regimen is highly effective for PrEP, and for HIV treatment when used alongside other antiretroviral drugs, it may not work or could even lead to serious complications if it is not taken correctly.

For emtricitabine and tenofovir DF to work as it is designed to, the correct dosage must be taken, and at the right time as well:

• for adults weighing 35 kg or more: you should take one tablet (containing 200 mg of FTC and 300 mg of TDF) orally with food or without it;
• for pre-exposure prophylaxis (PrEP): it’s necessary to take one tablet (containing 200 mg of FTC and 300 mg of TDF) daily orally with food or without it. Safe sex practices should also be followed to reduce the risk of getting infected even more.

Please discuss with your health care provider in order to determine the correct amount of dosage for all patients (adults and children). Any discomfort experienced with the usage of the tablets should be reported as well.

Side Effects of Medication

Alongside the good benefits of this drug, it may also lead to some adverse reactions. The possible side effects may range from manageable ones such as headaches, fatigue, and stomach upset, to more severe ones such as body aches, difficulty in breathing, and blisters under the skin. Regardless, because the benefit of this drug far outweighs its downside, it remains a trusted drug for the treatment of HIV and continues to be used.

Fortunately, new regimens for HIV treatment are developed every day, and they pose way fewer side effects than the older ones. With the use of newer regimens, infected individuals are less likely to suffer side effects.

Common side effects of this medication usually include:

• diarrhea;
• headache;
• rash;
• loss of voice;
• fever;
• fatigue;
• sore throat.

These effects may not be experienced by every user of this drug. For those who experience it, they may vanish within weeks of strict adherence to the medication, as the body makes an adjustment. Any form of discomfort (side effect) should be reported to a doctor or healthcare provider who may provide tips to help manage or prevent them.

Emtricitabine and Tenofovir Disoproxil PrEP Drug Interactions

Up till now, direct trials have not been carried on Truvada to determine how it interacts with other drugs, foods, and supplements. However, trials have been carried out on the individual active components of the drug (i.e. emtricitabine and tenofovir DF).

The clinically relevant drugs interactions with the two components include:

• patients who are taking both Truvada and didanosine concurrently should be monitored frequently for adverse reactions. Upon the occurrence of an adverse reaction, didanosine should be discontinued;
• Atanazir administered with Truvada is recommended to be taken along with ritonavir in order to reduce the fast clearance of atanazir in the blood;
• close observations have shown that co-administration of Truvada and some hepatitis C antiviral agents like epclusa and harvoni increase tenofovir exposure;
• there might be an increase in the concentration of emtricitabine and tenofovir when Truvada is co-administered by drugs that are eliminated by active tubular secretion. The concentration of the co-administered drug may rise too. Examples of these drugs are acyclovir, cidofovir, and aminoglycosides.

For complete information, contact your pharmacist.

Reviews of Users

A majority of active users of Truvada for PrEP have attested to its effectiveness in preventing HIV infections. A greater part of them have reported little or no side effects. Same goes to the HIV positive patients taking Truvada as part of their regimen.

However, a few people complained about experiencing dizziness, headaches, stomach upset, vomiting, or fatigue at the early stage of commencing the medication. While some of these users who made these complaints reported the disappearance of the side effects within a little over a week, others said the side effects took about two weeks to subside.

Overall, going by the reviews of very many emtricitabine and tenofovir DF users, the drug is considered to be very good in terms of both ease of use and its effectiveness in reducing the possibility of getting infected with HIV.

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