Sofosbuvir

Generic Sofosbuvir Pills for Hepatitis C

Hepatitis C virus (or HCV) infection is still a big challenge in the world health care system. Its prices are higher and it affects nearly 1% of the world’s total population. The good news is that generic sofosbuvir is the latest and most effective anti-HCV medication that addresses the high cost of treating HCV.

There are several other brand-name versions of sofosbuvir, including Sovaldi and Harvoni (in combination with another active ingredient - ledipasvir).

What Is Sofosbuvir Used for?

After being approval by the FDA in December 2013, sofosbuvir has become the ultimate medical indication essential for combating viral replication in HCV.

Generic sofosbuvir tablets are produced and marketed in India by Natco pharma limited under the name Hepcinat. Gilead Sciences sells the same medication under the brand-name Sovaldi. These two medications are fixed-doses of the main ingredient – 400 mg.

HCV increases the risks of liver-related illness, which may eventually lead to death. Chronic hepatitis C infection can cause severe liver complications like cirrhosis or liver cancer. It’s also connected with diverse extra-hepatic indications, which further undermine the patients’ health outcome and quality of life.

Generic sofosbuvir 400 mg drug is used with other antiviral medicines (such as peginterferon, ribavirin, and daclatasvir) to treat chronic hepatitis C – a viral infection of the liver. It functions by reducing the amount of HCV virus in a patient’s body, helping the immune system of the body fight the infection, thus letting the liver recover.

Generic sofosbuvir is fascinating to most health care professionals. It has an excellent therapeutic profile, making it the best treatment of HCV. Sofosbuvir has wider genotype/subtype coverage, is the best-known medication with very few drug-drug interactions (DDIs), and can be administered to patients with decompensated cirrhosis.

The tablet is taken once daily with pangenotypic DAAs potency. Moreover, this drug is used in combination with different types of NS3/4A protease or NS5A inhibitors, and/or ribavirin (RBV) to attain high SVR rates.

Mode of Action

Sofosbuvir has proven itself as the best remedy to treat hepatitis C virus compared to other hep C drugs. It is a direct-acting antiviral (DAA) drug used in patients with or without cirrhosis as part of a combination regimen to medicate adult patients with genotype (GT) 1, 2, 3, or 4.

Moreover, patients 12 years of age and older can use sofosbuvir as a combination regimen with ribavirin to treat genotypes 2 or 3 HCV without or with compensated cirrhosis.

As the usual mechanism of action of all nucleotide-like antiviral agents, Sovaldi finds and selectively attaches to a component of the virus that catalyzes the polymerization of RNA – the NS5B polymerase viral protein, which is part of the hepatitis C structure. In this way, it disguises itself as part of the NS5B (defective substrate) & inhibits its further development.

When the protein construction is suddenly stopped, it’s harder for the HCV to complete its normal action of replicating the virus. The immune system rebuilds and starts to destroy the number of HCV virus cells one at a time – they finally get eliminated and the patient's viral load gets to zero, which is a sign of the absence of the hepatitis C virus. The patient has fully recovered from the disease.

How to Take Sofosbuvir Correctly

Sofosbuvir cannot be taken on its own to cure hep C. It must be used as a part of therapy with other antiviral drugs like ribavirin or peginterferon alfa to treat hep C according to the patient’s genotype as shown in the table below.

Take one 400 mg tablet of sofosbuvir by mouth at the same time every day, regardless of meals, as directed by your doctor. The dosage should be based on your condition and response to treatment.

Sofosbuvir medication is administered for either 12 or 24 weeks (duration depends on virus genotype), or until your liver transplant if you are waiting for one. At best, it’s recommended that you effectively follow your doctor’s instructions when treating HCV.

Precautions and Contraindications

There are no clearly defined contraindications for generic sofosbuvir 400 mg when used alone. If your doctor recommends this pill in combination with ribavirin or combined with peginterferon alfa and ribavirin, or any other applicable drug, the contraindications relevant to these representatives are applied.

It’s important for your doctor or pharmacist to know your previous medical history, especially if you’ve previously been diagnosed with kidney or other liver disease, like hepatitis B. There is a high risk of hepatitis B virus reactivation in patients co-infected with HCV and HBV.

Inform your doctor for more details and analysis if you have any other medical allergies. Sofosbuvir pills may comprise inactive ingredients that can affect your health and cause allergic reactions or other problems.

Sofosbuvir may interact with some drugs. If you are using other over-the-counter drugs, prescription medications, or herbal meds, do let the doctor assess these medications before using sofosbuvir in order to avoid problems that may affect the hepatitis C treatment.

Sofosbuvir combined with ribavirin or peginterferon must not be used by pregnant women. Only use this medication when evidently needed during pregnancy.

There is no sufficient information if generic sofosbuvir medication get into breast milk. It’s recommended not to breastfeed while using sofosbuvir together with peginterferon or ribavirin.

Common Side Effects of Sofosbuvir

Various medicines have their possible side effects and may affect a patient in various ways. Below are some of unpleasant effects that are known to be associated with generic sofosbuvir pills when it is administered together with ribavirin, with or without peginterferon:

The following are common side effects affecting a small percentage of HCV patients when treated with sofosbuvir medication:

If you experience extreme side effects when using sofosbuvir in combination with peginterferon or ribavirin, consult your doctor or pharmacist immediately.

Interactions of HCV Drug

Depending on the patient's state of disease, various medications may affect how the drug functions, which may lead to various serious side effects. It’s important to stay away from other drugs that contain sofosbuvir when treating HCV.

The most common medicine that may interact with sofosbuvir is amiodarone. Some medications can affect the excretion of sofosbuvir from the patient body, thus affecting how generic sofosbuvir functions.

Examples of these drugs include St. John's wort, rifamycins (like rifampin and rifabutin), tipranavir/ritonavir, drugs for treating seizures (for example phenytoin, carbamazepine, primidone, and phenobarbital), as well as rifapentine, fosphenytoin, modafinil, and oxcarbazepine, among others.

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How to Buy Sofosbuvir at Cheap Price in the USA

In addition to this drug’s quality performance and effectiveness, the prices of generic sofosbuvir therapies are more than 80% cheaper compared to the original brand-name. That’s the principle of generic medications – to address the cost of treatment.

Based on these two advantages, the use of generic sofosbuvir regimens has facilitated mass treatment as it plays an important role in eliminating HCV infection in the world, particularly in developing nations across Asia and Africa where the cost of treating HCV was highly expensive.

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