Various antiretroviral drugs have been developed over the years to help patients infected with the human immunodeficiency virus (HIV) live longer and more fulfilling lives. Maximune saquinavir 500 mg is one of such drugs and it’s highly effective.
When used in combination with other antiretrovirals like ritonavir, it helps lower the risk of spreading HIV to non-infected persons and also improves the immune system of the patient by lowering the multiplication rate of the virus within the body. If this drug is used exactly as prescribed, it can help HIV patients achieve an undetectable viral load.
Formula of Saquinavir Maximune 500 mg Drug
Saquinavir Maximune is an antiretroviral drug categorized under the class of protease inhibitors. It acts against or inhibits the HIV types 1 and 2 proteases by binding to them in the body of the infected patient. Saquinavir Maximune 500 mg is a film-coated type of tablet for oral consumption.
Each 500 mg tab formula contains inactive ingredients: magnesium stearate, lactose, Povidone K30, microcrystalline cellulose, Croscarmellose sodium. The film-coating consists of iron oxide yellow, Hypromellose, talc, titanium dioxide, triacetin and iron oxide red.
Mode of Action
The mechanism of action of saquinavir can best be understood if the process of HIV infection is grasped.
Once introduced to the body, HIV strives to bind with small chunks of proteins so as to create more copies of itself. However for this to take place, it requires an enzyme known as protease. This enzyme is responsible for breaking down large precursor proteins into the smaller proteins that the virus can fuse with. This process is an important part of the life cycle of the virus, and once this is achieved, it starts replicating and infecting other cells. The now growing virus launches an attack on the T-cells (CD4+ cells) of the infected individual, gradually destroying the immune system. This process goes on and on until the immune system completely loses its ability to defend the body against the least of diseases.
Maximune saquinavir is able to disrupt the replication process of HIV-1 and HIV-2 by stopping the action of their proteases, thus preventing viruses from binding with smaller proteins. This way, the medication slows down or completely puts the replication process to an end.
Safe Dosage Instructions
It is advisable that medication with this drug is started at a low dose before gradually increasing with time in order to prevent the risk or dangers of side effects.
It is important that your healthcare provider is well aware of your medical history as a response to treatment with respect to drug strength and dosage, which differs from patient to patient. Also, the importance of keeping your doctor informed about any drugs (previously prescribed anti-HIV drugs, health supplements, herbal medicines or other non-prescribed meds) used before and during your intake of Maximune cannot be overemphasized. This can influence the prescription and dosage to be administered.
Do not at any point in time stop or cut off the use of this medication as it may lead to increased replication of the virus, thereby worsening the infection and making it more difficult to treat. Users are advised to strictly adhere to the directions and instructions in the drug package. Look out for side effects that may occur and inform your doctor immediately about mild or severe side effects.
Saquinavir Maximune tablet is best taken orally and at the same time with the co-administered antiretroviral drug, usually ritonavir. It should be taken twice daily, immediately after a meal or 2 hours after. Avoid overdosing or taking lesser amounts than required.
A daily dose of saquinavir Maximune should not exceed 1000 mg dosage which can be taken as 200 mg (hard-gel capsules) dosage five times a day or 500 mg (film-coated tablet) dosage twice a day. The medication should be taken in combination with 100 mg doses of ritonavir daily for better results.
Interactions of Maximune 500 mg with Other Drugs
Using different medications concomitantly can affect their functionality and increase the risk of negative after-effects by way of an interaction.
Drug interactions may pose great risk to a patient’s health and it is important to use drugs only prescribed by your doctor in combination with any antiretroviral drug. Some drugs that may interact with saquinavir Maximune include:
- products containing garlic, rifamycins (Rifampin, Rifapentine);
- benzodiazepines (Triazolam, Midazolam);
- ergot alkaloids medicine (which consists of dihydroergotamine, ergotamine, methylergonovine, ergonovine);
- St. John’s wort;
- specific statin cholesterol meds (Lovastatin, Simvastatin).
There are other drugs that can interact with Maximune. These drugs include: Quinidine, Propafenone, Pimozide, Amiodarone, Dofetilide, Flecainide, Cisapride, Clarithromycin, Salmeterol, Erythromycin, Tacrolimus, Pentamidine, among others.
The removal of saquinavir from your body may be influenced by other medications. Some of these medications include other HIV protease inhibitors like Indinavir, Tipranavir, Atazanavir, Nelfinavir, among others. Avoid using saquinavir Maximune if you have a heart condition, a history of liver disease including hepatitis B or C, or cases of low levels of magnesium and potassium in the blood. Also, do not use saquinavir in conjunction with cobicistat antiretroviral drug.
Saquinavir Maximune may also affect how other medications work in the body and may influence or decrease the rate of their removal. Drugs that may be affected include:
- medications used in the treatment of pulmonary hypertension or erectile dysfunction (ED). Drugs like Sildenafil, Tadalafil, Vardenafil, Naloxegol, Rilpivirine, Isavuconazonium, rivaroxaban, Suvorexant, amongst others.
This medication may reduce the efficiency of contraceptives such as patch, pills, or ring. This could lead to an unplanned pregnancy. Discuss other alternatives or supplementary forms of contraception, and always use adequate preventive method (polyurethane or condoms) during sex to avoid spreading HIV to non-infected persons. Inform your healthcare provider of any new bleeding or spotting, as it may mean that your birth control is not working properly.
Reviews of Customers
Though just like any other drug, Maximune comes with side effects that range from headaches to dizziness, nausea, upset stomach, vomiting and others not mentioned here, it has been received with open arms among most patients.
While a few users laid complaints about experiencing headaches that would not go away, and severe dizziness each time they take the tabs, there are those that say it is one of the best drugs they have had. The latter form a majority of the users of this med.
Generally, based on customer reviews, this drug is very satisfactory in terms of ease of use and positive effect.
Get Maximune 500 mg Drug for Affordable Cost
This medication is widely available and it can be bought from certain healthcare centers, as well as from online pharmacies, with or without a prescription. Being a generic of the brand name drug, Maximune is available at a very pocket-friendly price even though it offers exactly the same effectiveness, dose, mode of action, and side effects as Invirase – the brand name drug. However, even more money can be saved, depending on where you buy from.
Looking to get this highly effective drug at one of the best prices possible? Check out BuyPrEPOnline! Sourcing products directly from the manufacturer without a middle man, we’re able to provide our customers with the best prices.
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